In today's world, hormonal imbalances like estrogen dominance are becoming increasingly common due to plastic pollution and other environmental factors. Also, what our body does with its estrogens, (i.e. how it metabolizes them), can have a huge impact on whether they will be helpful, or have detrimental effects, such as mood swings, weight gain, PMS, hot flashes and increased risk of chronic health issues.
To naturally support hormone balance, Synergy Holistics offers DIM Synergy, providing two powerful compounds: Diindolylmethane (DIM) and Calcium D-Glucarate.
This highly beneficial combination not only addresses the modern-day estrogen burden we all face, but also enhances its detoxification.
Understanding Estrogen Dominance and Its Impact
Estrogen dominance occurs when the body has an excess of estrogen relative to other hormones. This effect is amplified by environmental pollutants known as xenoestrogens, found in plastics, pesticides, and household products. In the body these chemicals bind to estrogen receptors, and mimic estrogen's effects, creating imbalance. This can contribute to hormonal mood swings, weight gain, PMS and menopausal symptoms, to more severe conditions like endometriosis and prostate issues.
Estrogen also makes cells divide and multiply, which is why anticancer drugs like Tamoxifen block estrogen receptors. To address estrogen dominance naturally, one not only needs to reduce intake of estrogenic compounds, but also support the body's ability to eliminate them. This is where the synergistic action of DIM Synergy shines.
DIM: A Crucial Ally in Estrogen Metabolism
Diindolylmethane (DIM) is a natural compound derived from cruciferous vegetables like broccoli and cabbage. It has gained attention for its ability to simultaneously increase the body’s production of favorable, “good” estrogen metabolites, (known as 2-OH estrogens), which have a protective, anti-inflammatory effect. While at the same time helping to reduce the production of more aggressive, inflammatory, undesirable estrogen metabolites, (16-OH and 4-OH estrogens), linked to inflammation and cell proliferation.
By shifting estrogen metabolism to these "friendlier" metabolites, DIM effectively reduces negative estrogenic effects. DIM's anti-inflammatory properties make it particularly beneficial for addressing symptoms of PMS and menopause. For men, DIM’s benefits are well established for promoting prostate health and metabolic stability.
D-Glucarate: Enhancing Detoxification and Elimination
While DIM improves estrogen metabolism, Calcium D-Glucarate complements this action by promoting estrogen elimination. This process begins in the liver, where estrogens are joined with glucuronic acid - a derivative of D-Glucarate - so they can be escorted through our bile, and out the colon.
However, if a colon is "dysbiotic" (i.e.has high levels of undesirable bacteria), estrogen elimination can be halted by something called “beta-glucuronidase". This enzyme snips the bond joining estrogen and glucarate, allowing estrogen to be reabsorbed. D-Glucarate inhibits beta-glucuronidase, preventing such reabsorption and allowing for complete elimination. This reduces the body’s estrogenic burden.
The Synergistic Power of DIM and D-Glucarate
Together, DIM and D-Glucarate form a powerful duo for managing estrogen’s effects. DIM helps the body produce healthier estrogen metabolites, while D-Glucarate ensures that harmful estrogens and xenoestrogens are properly eliminated. Synergy Holistics harnesses these benefits in DIM Synergy.
Who Can Benefit from DIM Synergy?
DIM Synergy is ideal for a wide range of individuals:
- Women experiencing PMS or menopausal symptoms
- Men concerned with prostate health
- Individuals exposed to environmental pollutants
- People with a history of hormonal imbalances
How to Take DIM Synergy
Best taken with meals, Synergy Holistics recommends 1 capsule - once or twice daily. Please note that changes in urine color are normal with this product.
Companion Products: Probiotics Synergy and Liver Synergy.
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